10 papers reviewed
Specialty Lab Testing & Advanced Biomarkers
2015 · meta-analysis · 1 of 10
Factor V Leiden and prothrombin G20210A mutations and in vitro fertilization outcomes: a meta-analysis
Defined Qin et al. · Reproductive BioMedicine Online
Factor V Leiden mutation associated with increased risk of recurrent pregnancy loss (OR 2.0-3.0). Screening recommended in women with RPL. Prothrombin mutation also associated with adverse pregnancy outcomes.
Read the paper ↗2019 · cohort · 2 of 10
HOMA-IR is a predictor of reproductive outcomes in women undergoing in vitro fertilization
Cai J et al. · Reproductive BioMedicine Online
Elevated HOMA-IR (insulin resistance) independently predicted lower clinical pregnancy and live birth rates in IVF. Supports routine insulin resistance screening beyond standard glucose testing.
Read the paper ↗2018 · systematic review · 3 of 10
Oxidative stress biomarkers in the preconception, pregnancy, and postpartum periods: a systematic review
Aouache R et al. · International Journal of Environmental Research and Public Health
Elevated oxidative stress markers (MDA, 8-OHdG, ROS) and decreased antioxidant capacity (SOD, GPx, TAC) associated with infertility, miscarriage, preeclampsia, and IUGR. Supports oxidative stress panel in fertility workup.
Read the paper ↗2022 · critical review · 4 of 10
Endometrial receptivity analysis (ERA) test: an unproven technology
Doyle N et al. · Human Reproduction
ERA test for personalized embryo transfer timing has not been validated in large RCTs. Multiple studies show no improvement in live birth rates with ERA-guided transfer. Important cautionary evidence against routine use.
Read the paper ↗2020 · review · 5 of 10
Comprehensive chromosomal screening of sperm DNA fragmentation
Agarwal A et al. · World Journal of Men's Health
Sperm DNA fragmentation index (DFI) >30% associated with reduced pregnancy rates and increased miscarriage. SCD and SCSA are validated testing methods. Recommended when standard semen analysis is normal but fertility is unexplained.
Read the paper ↗2019 · systematic review · 6 of 10
Vaginal microbiome and its relationship to reproductive outcomes in IVF: a systematic review
Koedooder R et al. · Human Reproduction Update
Non-Lactobacillus-dominant vaginal microbiome associated with significantly lower implantation, pregnancy, and live birth rates in IVF. Vaginal microbiome testing may identify a modifiable factor in implantation failure.
Read the paper ↗2021 · systematic review · 7 of 10
The role of MTHFR C677T and A1298C polymorphisms in fertility and reproduction: a systematic review
Rai V · Journal of Reproduction & Infertility
MTHFR C677T homozygous variant associated with increased risk of recurrent pregnancy loss (OR 1.62) and neural tube defects. Testing informs whether methylfolate should replace folic acid.
Read the paper ↗2011 · prospective cohort · 8 of 10
Salivary cortisol patterns and reproductive outcomes in women undergoing IVF
An Y et al. · Psychoneuroendocrinology
Salivary cortisol testing captured stress-axis patterns that single morning serum cortisol misses. Elevated cortisol patterns associated with lower IVF pregnancy rates.
Read the paper ↗2018 · review · 9 of 10
Chronic endometritis: what is the role of CD138 immunostaining?
Liu Y et al. · Reproductive BioMedicine Online
CD138 immunohistochemistry on endometrial biopsy is the gold standard for chronic endometritis diagnosis, superior to H&E staining alone. CE prevalence 10-67% in women with unexplained infertility or RPL.
Read the paper ↗2018 · review · 10 of 10
Assessment of RBC magnesium: an important but underutilized clinical tool
Workinger JL et al. · Nutrients
Serum magnesium holds only 1% of body stores and is tightly defended. RBC magnesium is a more accurate measure of intracellular magnesium status but is rarely ordered. Normal serum magnesium excludes essentially nothing about true magnesium status.
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