5 papers reviewed
RPL - Additional Causes & Treatments
2025 · review · 1 of 5
Antiphospholipid syndrome in pregnancy: a comprehensive literature review
Various · BMC Pregnancy and Childbirth
APS is the most important treatable cause of recurrent miscarriage. Present in 15% of women with RPL. With correct diagnosis and treatment, 80-90% chance of successful pregnancy. Aspirin + heparin is standard treatment.
Read the paper ↗2019 · systematic review / meta-analysis · 2 of 5
Pregnancy outcomes in patients with primary antiphospholipid syndrome: a systematic review and meta-analysis
Various · Autoimmunity Reviews
Despite treatment, lupus anticoagulant positive patients have 30% adverse outcome risk. However, standardized treatment protocols significantly improve live birth rates across multiple studies.
Read the paper ↗2025 · review · 3 of 5
Immunological factors in recurrent pregnancy loss: mechanisms, controversies, and emerging therapies
Various · Biology (MDPI)
Comprehensive review of immune dysregulation in RPL: altered maternal-fetal tolerance, increased NK cell cytotoxicity, Th1/Th2 imbalance. Emerging therapies include HCQ, intralipids, and targeted immunomodulation.
Read the paper ↗2022 · RCT (phase 3) · 4 of 5
Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: a double-blind, randomized, placebo-controlled, phase 3 trial
Various · eClinicalMedicine (Lancet)
Phase 3 double-blind RCT of IVIG for women with 4+ pregnancy losses. Provides highest-quality evidence on IVIG for immune-mediated RPL.
Read the paper ↗2025 · cohort (propensity-matched) · 5 of 5
Early intravenous immunoglobulin use improves live birth outcomes in women with recurrent pregnancy loss: a propensity score-matched cohort study
Various · Reproductive Sciences
Early IVIG use improved live birth outcomes in RPL. Timing of immunotherapy initiation matters: earlier intervention may be more effective than delayed treatment.
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.