11 papers reviewed
Photobiomodulation / Red Light Therapy & Fertility
2012 · prospective case series · 1 of 11
Personal overview of the application of LLLT in severely infertile Japanese females
Ohshiro T · Laser Therapy
In 701 women (avg age 39, avg 9 years infertility, all failed ART), 830 nm laser applied to the neck achieved 22.3% pregnancy rate with 79 live deliveries. No adverse events in any patient. Largest PBM fertility dataset.
Read the paper ↗2024 · prospective case series · 2 of 11
The efficacy of multiwavelength red and near-infrared transdermal photobiomodulation light therapy in enhancing female fertility outcomes
Phypers R, Berisha-Muharremi V, Hanna R · Journal of Clinical Medicine
Multiwavelength red (630 nm) and NIR (850 nm) applied transabdominally during the follicular phase improved AMH levels, endometrial thickness, and hormonal profiles in age-related infertility, contributing to healthy live births.
Read the paper ↗2018 · in vitro experimental · 3 of 11
Has the time come to include low-level laser photobiomodulation as an adjuvant therapy in the treatment of impaired endometrial receptivity?
El Faham DA, Elnoury MAH, Morsy MI, et al. · Lasers in Medical Science
635 nm laser increased proliferation and functional capacity of cultured endometrial cells, with significantly altered expression of receptivity markers (MUC1, LIF, integrins). Suggests potential as adjuvant for thin endometrium.
Read the paper ↗2024 · animal + in vitro · 4 of 11
Photobiomodulation ameliorates ovarian aging by alleviating oxidative stress and inflammation damage and improving mitochondrial function
He Y, Ye R, Peng Y, et al. · Journal of Photochemistry and Photobiology B
650 nm laser recovered sex hormone levels, increased primordial and growing follicles, improved angiogenesis, increased mitochondrial membrane potential and ATP, and reduced oxidative stress in aged mice ovaries.
Read the paper ↗2025 · animal · 5 of 11
Near infrared LED irradiation reverses the declining quality of mice post-ovulatory aging and reproductive aged oocytes
Zhang N, You Y, Zhao Y, et al. · Biology of Reproduction
810 nm and 950 nm NIR restored mitochondrial membrane potential, optimized mitochondrial distribution, augmented ATP synthesis, reduced ROS, improved spindle organization, and enhanced fertilization capacity in aging oocytes.
Read the paper ↗2024 · experimental in vitro · 6 of 11
The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia
Stigliani S, Ravera S, Maccarini E, et al. · Scientific Reports
810 nm NIR at 1W and 2W most effective at increasing progressive sperm motility. PBM partially restored oxidative phosphorylation efficiency. Asthenozoospermic samples showed ~80% impaired ATP production at baseline; PBM partially reversed this.
Read the paper ↗2015 · clinical experimental · 7 of 11
Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia
Ban Frangez H, Frangez I, Verdenik I, et al. · Lasers in Medical Science
LED treatment (850 nm, 625/660 nm combinations) significantly increased rapidly progressive sperm in 30 men with asthenozoospermia. Improvements of 2.8-4.5 percentage points in progressive motility across all wavelength groups.
Read the paper ↗2020 · in vitro experimental · 8 of 11
Photobiomodulation with 810 nm wavelengths improves human sperms' motility and viability in vitro
Safian F, Ghaffari Novin M, Karimi M, et al. · Photobiomodulation, Photomedicine, and Laser Surgery
NIR laser at 0.6 J/cm2 was optimal for improving motility while preserving viability. Combined red+NIR at all doses decreased viability. Critical dose-response finding: lower dose = better outcomes.
Read the paper ↗2024 · in vitro controlled trial · 9 of 11
Improving human sperm motility via red and near-infrared laser irradiation: in-vitro study
Ahmed R, Hamdy O, Elattar S, Soliman AA · Photochemical and Photobiological Sciences
~70% motility increase with 650 nm, ~80% with 980 nm, ~100% with combined laser after 3 minutes. DNA integrity unaffected — no discernible effects on DNA fragmentation.
Read the paper ↗2020 · narrative review · 10 of 11
Photobiomodulation therapy for male infertility
Zupin L, Pascolo L, Luppi S, et al. · Lasers in Medical Science
PBM enhances spermatozoa metabolism, motility, and viability by activating mitochondrial cytochrome c oxidase and increasing ATP generation. Particular clinical utility in sperm culture and post-thaw survival.
Read the paper ↗2024 · systematic review · 11 of 11
A comprehensive systematic review of the effects of photobiomodulation therapy in different light wavelength ranges on sperm cell characteristics
Moradi A, Ghaffari Novin M, Bayat M · Reproductive Sciences
Red (620-750 nm) and NIR (750-1100 nm) show most consistent sperm improvements. Blue and green wavelengths show mixed results with potentially harmful effects at higher doses. Effects are dose- and wavelength-dependent.
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.