7 papers reviewed
Ovulation Support (Non-IVF)
2014 · RCT (multicenter, double-blind) · 1 of 7
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro RS et al. · New England Journal of Medicine
In 750 women with PCOS, letrozole had higher cumulative live birth rate (27.5% vs 19.1%; RR 1.44) and ovulation rate (61.7% vs 48.3%) compared to clomiphene. Letrozole should be first-line for PCOS ovulation induction.
Read the paper ↗2025 · narrative review · 2 of 7
Letrozole at the crossroads of efficacy and fetal safety in ovulation induction: a narrative review
Various · Cureus
Comprehensive review of letrozole for ovulation induction. Confirms efficacy while examining safety profile including low twin pregnancy rate (3% vs 7% for clomiphene).
Read the paper ↗2020 · cohort · 3 of 7
Effect of HCG-triggered ovulation on pregnancy outcomes in intrauterine insemination: an analysis of 5,610 first IUI natural cycles
Various · Frontiers in Endocrinology
HCG-triggered ovulation improved clinical pregnancy (27.4% vs 22.7%) and live birth rates (24.5% vs 20.1%) compared to spontaneous LH surge in natural cycle IUI. Pregnancy rate increased by ~31% with trigger timing.
Read the paper ↗2005 · meta-analysis · 4 of 7
Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis
Steiner AZ et al. · Human Reproduction
Tamoxifen and clomiphene are equally effective in inducing ovulation with similar pregnancy rates. No significant differences in luteal phase length or progesterone levels. Tamoxifen is a viable alternative.
Read the paper ↗2014 · RCT · 5 of 7
Comparison of the effectiveness of clomiphene citrate, tamoxifen and letrozole in ovulation induction in infertility due to isolated unovulation
Various · Reproductive Health
All three agents (clomiphene, tamoxifen, letrozole) effective for isolated anovulation. Letrozole showed advantages in endometrial thickness and lower multiple gestation risk.
Read the paper ↗2021 · review · 6 of 7
Prospective of low dose naltrexone use in treatment of autoimmune pathology and endometriosis
Various · Reproductive Endocrinology
LDN (1.5-4.5mg) exhibits anti-inflammatory and immune-modulating properties. Allows pain/inflammation management while patient continues to ovulate regularly. Compatible with active conception attempts.
Read the paper ↗1997 · meta-analysis · 7 of 7
Intrauterine insemination vs timed intercourse in superovulated cycles: a meta-analysis
Costello MF et al. · Fertility and Sterility
IUI shows better conception rates than timed intercourse in stimulated cycles overall, but timed intercourse increases pregnancy rate in patients with lower motile sperm count (<40 million).
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.