Nutrients the pill depletes

Combined oral contraceptives are associated with reduced levels of folate, vitamins B2/B6/B12/C/E, magnesium, selenium, and zinc. One study found approximately half of OCP users had B12 below the reference range despite being asymptomatic.

One important exception: estrogen-containing contraceptives actually increase vitamin D by about 20% through an effect on binding protein — so levels may drop after stopping. Vitamin D is not on the depletion list.

A repletion protocol starting before or when you stop — emphasizing methylfolate, B12, zinc, magnesium, and selenium — can help rebuild stores for conception. A combined selenium + vitamin E regimen has been shown to increase AMH and follicle count.