4 papers reviewed
Male Factor - Sperm DNA Integrity
2022 · systematic review / meta-analysis · 1 of 4
Antioxidant supplementation on sperm DNA fragmentation and sperm parameters: a systematic review and meta-analysis
Various · Reproductive Biology and Endocrinology
3-month antioxidant supplementation reduced DNA fragmentation in idiopathic infertility. Sperm concentration, motility, and morphology also improved. 4 of 9 studies showed statistically significant reduction.
Read the paper ↗2024 · RCT (double-blind) · 2 of 4
Sperm DNA integrity following a three months oral antioxidant supplementation: outcomes of a double blind, randomized clinical trial
Various · Reproductive BioMedicine Online
Double-blind RCT showing significant improvement in DNA integrity at all incubation points after 3 months of antioxidant supplementation. Proportion of highly degraded sperm significantly reduced.
Read the paper ↗2023 · review · 3 of 4
Micronutrient supplements as antioxidants in improving sperm quality and reducing DNA fragmentation
Various · Frontiers in Nutrition
Comprehensive review of micronutrient antioxidants (CoQ10, L-Carnitine, Zinc, Vitamin D, E, NAC) for reducing sperm DNA fragmentation. Antioxidants counteract oxidative stress and improve spermatogenesis.
Read the paper ↗2022 · pilot study · 4 of 4
The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study
Various · Andrology
Combined lifestyle intervention and antioxidant therapy improved sperm DNA fragmentation and reduced seminal oxidative stress. Supports multimodal approach (supplements + lifestyle changes) for male factor.
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.