13 papers reviewed
Inflammation, Autoimmunity & Fertility
2025 · review · 1 of 13
Chronic endometritis diagnosis and fertility outcomes: an old unresolved question
Various · Reproduction and Fertility
Chronic endometritis is implicated in infertility, RIF, and RPL. Prevalence 10-67% in RIF/RPL populations and up to 50% in unexplained infertility. Antibiotics significantly improve pregnancy outcomes.
Read the paper ↗2018 · cohort · 2 of 13
Chronic endometritis in patients with unexplained infertility: prevalence and effects of antibiotic treatment on spontaneous conception
Cicinelli E et al. · American Journal of Reproductive Immunology
Pooled CE prevalence of 56.8% in unexplained infertility. Antibiotics resolved CE in 82.3% of patients. After successful treatment: 61.3% clinical pregnancy rate and 60% take-home baby rate.
Read the paper ↗2023 · cohort · 3 of 13
The effect of chronic endometritis and treatment on patients with unexplained infertility
Various · BMC Women's Health
CE prevalence of 51.7% in unexplained infertility group vs 28.6% in controls. Diagnosis and treatment improve spontaneous pregnancy rate and live birth rate.
Read the paper ↗2025 · review · 4 of 13
Biomarkers for endometrial receptivity: implications for infertility, implantation failure, and advances in diagnosis and treatment
Various · International Journal of Molecular Sciences
Key receptivity markers (HOXA10, HOXA11, LIF, IGFBP-1) are downregulated in chronic endometritis. Inflammatory conditions, endometriosis, and PCOS all compromise endometrial receptivity.
Read the paper ↗2021 · review · 5 of 13
Approaches to improve endometrial receptivity in case of repeated implantation failures
Various · Frontiers in Cell and Developmental Biology
Immune cells (NK cells, macrophages, T cells) play critical roles in endometrial receptivity. Immunological and inflammatory factors are major causes of RIF. Endometrial scratching and immunomodulation show promise.
Read the paper ↗2011 · cohort · 6 of 13
Increased prevalence of celiac disease in patients with unexplained infertility in the United States
Singh P et al. · Journal of Clinical Gastroenterology
Significantly increased prevalence (5.9%) of undiagnosed celiac disease among women with unexplained infertility, compared to ~1% in general population. Supports screening in unexplained infertility.
Read the paper ↗2017 · cohort · 7 of 13
Unexplained infertility and undiagnosed celiac disease: study of a multiethnic Canadian population
Lasa JS et al. · Journal of Obstetrics and Gynecology Canada
Celiac disease was NOT more common in women with unexplained infertility than those with identified causes in this Canadian cohort. Conflicting evidence: prevalence estimates range 2-6% in unexplained infertility vs 1% general population.
Read the paper ↗2025 · review · 8 of 13
Fertility in celiac disease: the impact of gluten on male and female reproductive health
Various · Nutrients
Untreated celiac disease may contribute to infertility; gluten-free diet might improve fertility outcomes. However, overall infertility prevalence in celiac patients may not exceed general population.
Read the paper ↗2024 · umbrella review · 9 of 13
Autoimmune diseases and adverse pregnancy outcomes: an umbrella review
Various · BMC Medicine
Associations between 12 autoimmune conditions and 16 adverse pregnancy outcomes. Higher miscarriage risk with Sjogren's and SLE. Pre-eclampsia higher with T1DM and SLE. Autoimmune conditions warrant pregnancy monitoring.
Read the paper ↗2024 · systematic review / meta-analysis · 10 of 13
Pregnancy complications and autoimmune diseases in women: systematic review and meta-analysis
Various · BMC Pregnancy and Childbirth
Comprehensive meta-analysis confirming increased pregnancy complication risks across multiple autoimmune conditions. Supports integrating autoimmune screening into fertility workup.
Read the paper ↗2016 · systematic review · 11 of 13
Female infertility and serum auto-antibodies: a systematic review
Various · Clinical Reviews in Allergy & Immunology
Anti-phospholipid and anti-nuclear antibodies are more frequent in infertile women and associated with early ovarian failure. APS and SLE play crucial roles in infertility management.
Read the paper ↗2022 · cohort (from multicenter trial) · 12 of 13
High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial
Various · F&S Reports
Higher hs-CRP associated with increased pregnancy loss risk (dose-response: CRP 1-3 mg/L RR 1.67; >3-10 mg/L RR 1.84; >10 mg/L RR 2.14). Low-dose aspirin improved live birth rates in women with hs-CRP >= 1.95 mg/L.
Read the paper ↗2023 · cohort · 13 of 13
Serum C-reactive protein levels are associated with clinical pregnancy rate after in vitro fertilization among normal-weight women
Various · Journal of Assisted Reproduction and Genetics
CRP levels associated with clinical pregnancy rates in normal-weight women. BMI is a significant confounder of CRP-fertility relationship. Suggests chronic inflammation independent of BMI may impact fertility.
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.