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11 papers reviewed

Exercise & Cycle Phase Physiology

2020 · systematic review / meta-analysis · 1 of 11

The effects of menstrual cycle phase on exercise performance in eumenorrheic women: a systematic review and meta-analysis

McNulty KL et al. · Sports Medicine

Across 78 studies, performance dips in early follicular phase were statistically detectable but trivially small and not practically meaningful for most women.

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2023 · umbrella review · 2 of 11

The effect of the menstrual cycle on exercise metabolism and performance: a systematic review and umbrella review

Colenso-Semple LP et al. · Frontiers in Sports and Active Living

No reliable evidence that any cycle phase changes strength performance or training adaptations. Most studies lack hormone verification and have small sample sizes.

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2017 · meta-analysis · 3 of 11

ACL and MCL injuries of the knee: epidemiology, mechanisms of injury, and the role of hormonal factors in female athletes

Herzberg SD et al. · Orthopaedic Journal of Sports Medicine

ACL/knee laxity significantly higher at ovulation when estrogen peaks. Luteal phase had lowest injury association. Relevant for high-impact activity awareness around ovulation.

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2020 · review · 4 of 11

Thermoregulation during the menstrual cycle and implications for exercise performance

Baker FC, Siboza F, Fuller A · Temperature

Core temperature 0.3-0.7 degrees C higher in luteal phase due to progesterone. Heat tolerance measurably reduced. Relevant for hydration and workout intensity adjustments.

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2003 · review · 5 of 11

Exercise and the menstrual cycle

Janse de Jonge XAK · Sports Medicine

Established that hormone-verified studies find more consistent cycle-phase effects than calendar-based studies. Foundational reference for cycle-exercise research methodology.

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2017 · RCT · 6 of 11

Resistance training with single vs. multi-set loads: does training to failure matter?

Wikstrom-Frisen L et al. · Journal of Sports Medicine and Physical Fitness

Leg trained with higher frequency during follicular phase gained more strength and muscle size than leg trained with higher frequency during luteal phase. Early evidence for follicular-phase strength training advantage.

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2022 · critical review · 7 of 11

Does menstrual cycle phase-based resistance training enhance muscle hypertrophy? A critical review

Kissow J et al. · Sports Medicine

Plausible but unproven follicular-phase edge for muscle hypertrophy. Existing studies have significant methodological limitations including lack of hormone verification.

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2026 · RCT · 8 of 11

Training volume, not cycle phase, drives strength and hypertrophy gains in resistance-trained women

D'Souza AC et al. · Medicine & Science in Sports & Exercise

Training volume, not cycle phase, drives strength and hypertrophy gains. One of the newest, most rigorous studies actively debunking rigid cycle-syncing for strength training.

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2025 · RCT (muscle biopsy) · 9 of 11

Resistance exercise augments muscle protein synthesis equally in eumenorrheic women in the follicular and luteal phases

Colenso-Semple LP et al. · Journal of Physiology

Resistance exercise raised muscle protein synthesis equally in follicular and luteal phases using direct muscle biopsy measurement. The strongest single debunk of claims to build muscle better in one phase vs another.

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2021 · review · 10 of 11

Sex hormones and exercise performance in elite female athletes

Meignie A et al. · Frontiers in Physiology

Only 7 studies exist specifically on elite female athletes and cycle-phase performance. Evidence remains thin even in high-performance populations.

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2024 · cohort (polysomnography) · 11 of 11

Sleep architecture across the menstrual cycle: the EPISONO cohort

Ishikura K et al. · Sleep and Breathing

Sleep efficiency approximately 90% in follicular phase vs 83-84% in menses and luteal phases. Provides physiological basis for adjusting recovery expectations across the cycle.

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A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.