13 papers reviewed
Endometriosis - Identification and Treatment
2015 · cohort · 1 of 13
The surgical treatment of severe endometriosis positively affects the chance of natural or assisted pregnancy postoperatively
Soriano D et al. · Journal of Minimally Invasive Gynecology
Overall postoperative pregnancy rate of 57.3% and live birth rate of 51.9% within one year. Rates notably higher for stages I-II. Demonstrates surgical excision can restore natural fertility.
Read the paper ↗2022 · review · 2 of 13
Deep endometriosis and infertility: what is the impact of surgery?
Various · Journal of Clinical Medicine
In 1,548 women with deep endometriosis, 814 became pregnant (mean rate 52.6%). For deep infiltrating endometriosis specifically, pregnancy and live birth rates were 60.6% and 53.9%.
Read the paper ↗2025 · cohort · 3 of 13
Factors associated with spontaneous conception leading to live birth in infertility patients after endometriosis surgery
Various · Journal of Minimally Invasive Gynecology
Live birth rate within 12 months after endometriosis surgery was 40% (40/100 patients). Age <35 at surgery increased likelihood of live birth. Supports surgical treatment to restore natural fertility.
Read the paper ↗2024 · clinical commentary · 4 of 13
NaProTechnology Surgery: A Restorative Approach to Fertility and Gynecologic Health
RRM Academy · RRM Academy Commentary
NaPro surgical approach uses 'near-contact' laparoscopy for tissue preservation and adhesion prevention. Reduces scar tissue formation compared to conventional approaches. Outcomes heavily dependent on surgeon expertise.
Read the paper ↗2023 · cohort · 5 of 13
Mediterranean diet and oxidative stress: a relationship with pain perception in endometriosis
Various · Nutrients
After 3 months on Mediterranean diet, patients reduced pain in dyspareunia, non-menstrual pelvic pain, dysuria, and dyschezia. Further improvement at 6 months. Anti-inflammatory diet shows promise.
Read the paper ↗2022 · review · 6 of 13
I am the 1 in 10: what should I eat? A research review of nutrition in endometriosis
Various · Nutrients
High intake of PUFAs, gluten-free diet, and low nickel diet associated with improved pain management. Omega-3 PUFAs regulate prostaglandin metabolism and cytokine physiology, producing anti-inflammatory mediators.
Read the paper ↗2020 · pilot RCT · 7 of 13
A two-arm parallel double-blind randomized controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)
Nodler JL et al. · PLOS One
Pilot RCT of 33 women: omega-3 PUFA (1000mg twice daily) vs placebo for endometriosis pain. Omega-3s have no adverse effects on fertility while potentially reducing pain through anti-inflammatory mechanisms.
Read the paper ↗2019 · review · 8 of 13
Discovery of non-invasive biomarkers for the diagnosis of endometriosis
Anastasiu CV et al. · Clinical Proteomics
CA125 remains best single non-invasive marker (AUC 0.63). Multi-marker models improve AUC to 0.71-0.81 depending on cycle phase. No single biomarker has sufficient sensitivity/specificity alone.
Read the paper ↗2022 · biomarker study · 9 of 13
Antibody arrays identified cycle-dependent plasma biomarker candidates of peritoneal endometriosis
Various · Journal of Clinical Medicine
Identified cycle-dependent plasma biomarker candidates for endometriosis. Menstrual cycle phase is critical for biomarker interpretation. Cycle charting could enhance diagnostic accuracy.
Read the paper ↗2019 · clinical trial protocol · 10 of 13
Low-dose naltrexone in combination with standard treatment in women with endometriosis
Various · ClinicalTrials.gov (NCT03970330)
Clinical trial investigating LDN (1.5-4.5mg) for endometriosis. LDN blocks TLR4 in glial cells, modulates immune response, and manages pain/inflammation while allowing continued ovulation (fertility-preserving).
Read the paper ↗2025 · retrospective cohort · 11 of 13
Ablation compared with excision in the surgical management of peritoneal endometriosis: a retrospective study of pain, re-operation, and pregnancy outcomes
Various · BMC Women's Health
Excision had lower recurrence rates than ablation for peritoneal endometriosis. For stage 1-2 disease, recurrence was 63% after excision vs 84.8% after ablation. Supports excision as preferred approach for fertility preservation.
Read the paper ↗2024 · review · 12 of 13
Endometriosis surgery and fertility outcomes: an evidence-based review
Various · Fertility Science and Research
Evidence-based review confirming surgical excision improves fertility outcomes. Excision reduces inflammatory cytokines and recurrence risk compared to ablation. Outcome depends heavily on surgical expertise.
Read the paper ↗2010 · case series · 13 of 13
Near adhesion-free reconstructive pelvic surgery: three distinct phases of progress over 23 years
Hilgers TW · Journal of Gynecological Surgery
Hilgers' near-contact laparoscopy technique achieved <7% endometriosis recurrence rate. 23 years of progressive refinement in adhesion-prevention techniques for fertility-preserving surgery.
Read the paper ↗A paper's presence documents the evidence reviewed; it does not mean Filia endorses every intervention or conclusion.